Three-Dimensional Microscaffolds Exhibiting Spatially Resolved Surface Chemistry
- Author: B. Richter, T. Pauloehrl, J. Kaschke, D. Fichtner, J. Fischer, A.M. Greiner, D. Wedlich, M. Wegener, G. Delaittre, C. Barner-Kowollik, and M. Bastmeyer
- Source: Adv. Mater. 42, 6117–6122 (2013)
- Date: 4.09.2013
Spatial control over the surface chemistry of 3D organic–inorganic hybrid microscaffolds is achieved by a two-photon-triggered cycloaddition. Following a coating step with photoactivatable dienes via silanization, surface irradiation with a femtosecond-pulsed laser in the presence of functional dienophiles enables a site-selective alteration of the surface chemistry. Bioconjugation with fluorescent protein tags is employed to reveal the 3D molecular patterns.