Institute for Applied Physics - Research Group Prof. Dr. Nienhaus

Institute for Applied Physics - Research Group Prof. Dr. Nienhaus

Welcome to the Group of Prof. Dr. Nienhaus

associated group at the Institute of NanoTechnology (INT KIT)

Life processes in cells and organisms Nanoparticles and fluorescent proteins Quantitative optical microscopy
STED Microscopy Localization Microscopy (PALM/STORM) Light-sheet Microscopy (LSM)

We are looking for Students and Postdocs to work on our projects

We have exciting topics for Bachelor- and Master thesis.




PhD Position in Super-resolution RNA Imaging


Genetically encodable fluorescence markers for imaging of specific RNA molecules in live cells are still very limited. Within the project ‘Super‐resolution RNA Imaging with Aptamer‐ PAINT’, funded by the Baden‐Württemberg Stiftung (collaboration with the Jäschke lab, IPMB, U Heidelberg), we develop advanced light‐up RNA aptamers for live‐cell superresolution localization microscopy applications.

We are looking for an excellent, highly motivated person with a degree in (bio)physics, physical chemistry or related fields who is interested in working in an interdisciplinary team and who is strongly committed to careful biophysical experimentation (single molecule imaging) and computer‐based quantitative data acquisition and analysis.

Wirth, R.; Gao, P., Nienhaus, G. U., Sunbul, M. and A. Jäschke. SiRA: A Silicon Rhodamine‐ Binding Aptamer for Live‐Cell Super‐Resolution RNA Imaging. J. Am. Chem. Soc. 141, 7562 (2019)
Sunbul, M., Lackner, J., Martin, A., Englert, D., Hacene, B., Grün, F., Nienhaus, K., Nienhaus, G. U., & A. Jäschke. Super‐resolution RNA imaging using a rhodamine‐binding aptamer with fast exchange kinetics. Nature Biotechnol., in press.


Contact: uli.nienhaus∂



PhD Position in Advanced Fluorescence Microscopy

We are looking for excellent applicants with a Master‘s degree in
physics/biophysics (and related disciplines) who are strongly committed to
the development and application of optical microscopes, careful
experimentation and computer‐based quantitative data acquisition and
Für weitere Informationen: uli.nienhaus∂